Adipose-Derived Stromal Cells Accelerate Wound Healing in an Organotypic Raft Culture Model
نویسندگان
چکیده
منابع مشابه
Adipose-derived Stromal Cells Promote Survival of Endothelial Cells and Keratinocytes in Wound Healing Model
Burn wounds are a significant medical challenge today. Current treatment includes the use of skin grafts or wound healing scaffolds to protect the wound and promote healing. However, pre-existing conditions and factors such as smoking can compromise normal healing thru decreased growth factor production, prolonged inflammation, tissue hypoxia, reduced cellular migration and ECM deposition, and ...
متن کاملAdipose derived stromal vascular fraction improves early tendon healing: an experimental study in rabbits
Tendon never restores the complete biological and mechanical properties after healing. Bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. Stromal vascular fraction (SVF), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...
متن کاملAbstract 99: Isolation of CD248 Expressing Adipose Derived Stromal Cells for Targeted Improvement of Wound Healing
PURPOSE: Large surface area wounds, resulting from burns, trauma, or iatrogenic injury, often result in significant scarring and wound contracture. Despite treatment with any of the currently available gold-standard therapies, contracture can still develop as a sequelae of the process of normal wound healing, specifically, myofibroblast activity. Photochemical Tissue Passivation (PTP) is a proc...
متن کاملCell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing.
OBJECTIVE We hypothesized that adipose tissue may contain progenitors cells with cutaneous and angiogenic potential. METHODS AND RESULTS Adipose tissue-derived stroma cells (ADSCs) were administrated to skin punched wounds of both nonirradiated and irradiated mice (20 Gy, locally). At day 14, ADSCs promoted dermal wound healing and enhanced wound closure, viscolesticity, and collagen tissue s...
متن کاملEffects of Adipose-derived Stromal Cells and of their Extract on Wound Healing in a Mouse Model
In this study, the authors investigated the effects of adipose-derived stromal cells (ADSCs) and of their extract on wound healing. After creating wound healing splint model on the backs of mice, ADSCs and their extract were applied. Wound healing rates were calculated at 3, 5, 7, 10, and 14 days after the wounding, and tissues were harvested at 7 and 14 days for histological analysis. Wound he...
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ژورنال
عنوان ژورنال: Annals of Plastic Surgery
سال: 2012
ISSN: 0148-7043
DOI: 10.1097/sap.0b013e31823b69fc